Saliva is Mandy's dog. He drools a lot and likes Mandy a lot, even if she doesn't feel the same way. Saliva is a very emotional dog (he became very sad when Mandy got a new dog, Cerberus). He has shown that he was more loyal to his owner than both Cerberus and Mindy's pet poodle. Saliva has scared Mindy before by giving her a horrible, disgusting look that made her flee and Mandy admits she likes his loyalty to her. Saliva is only person Mandy shows any form of love or affection to. As well as drooling he has a snotty, runny nose.
Saliva is voiced by Frank Welker earlier in the show and Richard Steven Horvitz except in one episode; in which Saliva is voiced by Jess Harnell.