The Bride of Frankenstein is one of the monsters at the Home of the Ancients retirement center. She was friends with Dracula and the Wolfman. Her arms and legs aren't well connected to her body and usually fall off. She appears in Billy & Mandy's Big Boogey Adventure as a member of the jury.
- The Bride of Frankenstein originates from a 1935 movie of the same name.
- Technically, the Bride of Frankenstein is not the wife of the monster, but rather the wife of the scientist; this is because the monster is not named Frankenstein, despite the misconception that he is.
- Despite being visibly older, her mate the Frankenstein monster often appears within the show in his standard depiction and doesn't live in the Home of the Ancients.
- The Bride of Frankenstein seems to be a combination of her namesake monster and the actual Frankenstein's monster; this mostly comes from the fact that she freaks out around fire (often screaming "Fire bad!"), much like Frankenstein's monster, and she often falls apart like the monster.